NIH SBIR/STTR Phase II
National Institutes of Health·United States
NIH development award with a $2,153,927 budget guideline over 1 to 3 years, continuing R&D started under Phase I.
What you get
“A Phase II budget is $2,153,927 for a project timeline between 1 to 3 years.”
Can you apply
Only United States small business concerns are eligible to submit applications to SBIR and STTR solicitations. A small business concern is one that, at the time of award of Phase I and Phase II, meets all of the below criteria, as well as the Phase I to Phase II Transition Benchmark Rate: Is organized for profit, with a place of business located in the United States ... Be a concern which is more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States) ... Has, including its affiliates, not more than 500 employees. Small business concerns that are more than 50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these are NOT eligible to apply to the NIH STTR program.
When
Not open yet. The next round is listed below.
Upcoming
- Standard due date April 2027closes 5 Apr 2027 · 249 days left
- Standard due date January 2027closes 5 Jan 2027 · 159 days left
- Standard due date September 2026closes 8 Sept 2026 · 40 days left
What National Institutes of Health funds
NIH sets aside more than $1.4 billion of its R&D budget for the SBIR and STTR small business programs, funding U.S. small businesses building biomedical innovations from research tools and digital health software to diagnostics, drugs and devices. Non-dilutive: NIH takes no ownership of the business.
Everything National Institutes of Health funds →Details
A Phase II application may be submitted once Phase I milestones are reached, even before the Phase I award ends, and up to six receipt dates after the Phase I budget period expires. Companies that have already demonstrated feasibility without an NIH Phase I can apply through Direct to Phase II. Some Institutes and Centers offer Phase IIB Strategic Breakthrough awards beyond the standard 2-year Phase II period. Individual Institutes and Centers can set their own budget limits, and NIH holds an SBA waiver allowing larger awards on approved waiver topics.